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Article

Mitochondrial DNA variants can mediate methylation status of inflammation, angiogenesis and signaling genes.

Human molecular genetics - 15 Aug 2015

Atilano Shari R, Malik Deepika, Chwa Marilyn, Cáceres-Del-Carpio Javier, Nesburn Anthony B, Boyer David S, Kuppermann Baruch D, Jazwinski S Michal, Miceli Michael V, Wallace Douglas C, Udar Nitin, Kenney M Cristina

Abstract excerpt

Mitochondrial (mt) DNA can be classified into haplogroups representing different geographic and/or racial origins of populations. The H haplogroup is protective against age-related macular degeneration (AMD), while the J haplogroup is high risk for AMD. In the present study, we performed comparison analyses of human retinal cell cybrids, which possess identical nuclei, but mtDNA from subjects with either the H or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 25964427
DOI: 10.1093/hmg/ddv173
PMCID: PMC4512622

Genes

CFH
EFEMP1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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