Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.

doi:10.1016/j.bbadis.2013.10.016

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Article

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.

Biochimica et biophysica acta - 1 Feb 2014

Kenney M Cristina, Chwa Marilyn, Atilano Shari R, Falatoonzadeh Payam, Ramirez Claudio, Malik Deepika, Tarek Mohamed, Del Carpio Javier Cáceres, Nesburn Anthony B, Boyer David S, Kuppermann Baruch D, Vawter Marquis P, Jazwinski S Michal, Miceli Michael V, Wallace Douglas C, Udar Nitin

Abstract excerpt

The geographic origins of populations can be identified by their maternally inherited mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic hybrids), which are cell lines with identical nuclei but mitochondria from different individuals with mtDNA from either the H haplogroup or L haplogroup backgrounds. The most common European haplogroup is H while individuals of maternal African...

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PMID: 24200652
DOI: 10.1016/j.bbadis.2013.10.016
PMCID: PMC4326177

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