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Article

Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.

Investigative ophthalmology & visual science - 10 Jun 2014

Li Yi-Ju, Minear Mollie A, Qin Xuejun, Rimmler Jacqueline, Hauser Michael A, Allingham R Rand, Igo Robert P, Lass Jonathan H, Iyengar Sudha K, Klintworth Gordon K, Afshari Natalie A, Gregory Simon G

Abstract excerpt

PURPOSE: We investigated whether mitochondrial DNA (mtDNA) variants affect the susceptibility of Fuchs endothelial corneal dystrophy (FECD). METHODS: Ten mtDNA variants defining European haplogroups were genotyped in a discovery dataset consisting of 530 cases and 498 controls of European descent from the Duke FECD cohort. Association tests for mtDNA markers and haplogroups were performed using logistic...

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Identifiers

PMID: 24917144
DOI: 10.1167/iovs.13-13517
PMCID: PMC4109404

Genes

TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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