Article
Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Kawahara Kohichi, Suenobu Michita, Ohtsuka Hideyuki, Kuniyasu Akihiko, Sugimoto Yukihiko, Nakagomi Madoka, Fukasawa Hiroshi, Shudo Koichi, Nakayama Hitoshi
Abstract excerpt
Alzheimer's disease (AD) is a neurodegenerative process involving amyloid-β (Aβ) peptide deposition, neuroinflammation, and progressive memory loss. Here, we evaluated whether oral administration of retinoic acid receptor (RAR)α,β agonist Am80 (tamibarotene) or specific retinoid X receptor (RXR)...
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