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Article

Folic Acid potentiates the effect of memantine on spatial learning and neuronal protection in an Alzheimer's disease transgenic model.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Chen Ta-Fu, Huang Rwei-Fen S, Lin Sey-En, Lu Jyh-Feng, Tang Ming-Chi, Chiu Ming-Jang

Abstract excerpt

Folic acid deficiency and hyperhomocysteinemia potentiate amyloid-beta (Abeta) neuron toxicity. Memantine, an NMDA antagonist used in moderate to severe AD, is considered to be neuroprotective. We propose that folic acid might have a synergistic effect for memantine in protecting neurons from Abe...

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Identifiers

PMID: 20164552
DOI: 10.3233/JAD-2010-1396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20164552-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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