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Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study.

Cancer causes & control : CCC - 1 Sept 2014

Jung Audrey Y, van Duijnhoven Fränzel J B, Nagengast Fokko M, Botma Akke, Heine-Bröring Renate C, Kleibeuker Jan H, Vasen Hans F A, Harryvan Jan L, Winkels Renate M, Kampman Ellen

Abstract excerpt

PURPOSE: Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high lifetime risk of developing neoplasms. The role of MTHFR C677T genotype in modifying these relationships in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24916333
DOI: 10.1007/s10552-014-0412-4

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MTHFR

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