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Article

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.

Acta neuropathologica communications - 10 Jun 2014

Rudinskiy Nikita, Hawkes Jonathan M, Wegmann Susanne, Kuchibhotla Kishore V, Muzikansky Alona, Betensky Rebecca A, Spires-Jones Tara L, Hyman Bradley T

Abstract excerpt

Intraneuronal neurofibrillary tangles (NFTs) - a characteristic pathological feature of Alzheimer's and several other neurodegenerative diseases - are considered a major target for drug development. Tangle load correlates well with the severity of cognitive symptoms and mouse models of tauopathy are behaviorally impaired. However, there is little evidence that NFTs directly impact physiological properties of host...

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Identifiers

PMID: 24915991
DOI: 10.1186/2051-5960-2-63
PMCID: PMC4229905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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