Article
JAK-1 rs2780895 C-related genotype and allele but not JAK-1 rs10789166, rs4916008, rs2780885, rs17127114, and rs3806277 are associated with higher susceptibility to asthma.
Genetic testing and molecular biomarkers - 1 Dec 2011
Hsieh Yao-Yuan, Chang Chi-Chen, Hsu Chin-Mu, Wan Lei, Chen Shih-Yin, Lin Wen-Hsin, Tsai Fuu-Jen
Abstract excerpt
BACKGROUND: Asthma, one major respiratory consequence, might be caused by a complex interaction between multiple candidate genes and environmental factors. Herein, we aimed to investigate whether Janus kinase (JAK)-1 gene polymorphisms are associated with asthma susceptibility. MATERIALS AND METHODS: Patients were divided into two groups: (1) asthma (n=117) and (2) nonasthma (n=60). The JAK-1 polymorphisms...
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