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Polymorphism in interleukin-7 receptor α gene is associated with faster CD4⁺ T-cell recovery after initiation of combination antiretroviral therapy.

AIDS (London, England) - 31 Jul 2014

Hartling Hans J, Thørner Lise W, Erikstrup Christian, Harritshøj Lene H, Kronborg Gitte, Pedersen Court, Larsen Carsten S, Helleberg Marie, Gerstoft Jan, Obel Niels, Ullum Henrik, Nielsen Susanne D

Abstract excerpt

OBJECTIVES: To investigate single-nucleotide polymorphisms (SNPs) in the gene encoding interleukin-7 receptor α (IL7RA) as predictors for CD4⁺ T-cell change after initiation of combination antiretroviral therapy (cART) in HIV-infected whites. DESIGN: SNPs in IL7RA were determined in the Danish HIV Cohort Study. METHODS: CD4⁺ T-cell changes were estimated 6 months, 1, 2, and 5 years after initiation of cART in...

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PMID: 24911352
DOI: 10.1097/QAD.0000000000000354

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