Gene variation in IL-7 receptor (IL-7R)α affects IL-7R response in CD4+ T cells in HIV-infected individuals.

doi:10.1038/srep42036

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Article

Gene variation in IL-7 receptor (IL-7R)α affects IL-7R response in CD4+ T cells in HIV-infected individuals.

Scientific reports - 9 Feb 2017

Hartling Hans Jakob, Ryder Lars P, Ullum Henrik, Ødum Niels, Nielsen Susanne Dam

Abstract excerpt

Optimal CD4+ T cell recovery after initiating combination antiretroviral treatment (cART) in HIV infection reduces risk of morbidity and mortality. T-allele homozygosity ('TT') in the single nucleotide polymorphism, rs6897932(C/T), in the IL-7 receptor α (IL-7RA) is associated with faster CD4+ T cell recovery after cART initiation compared to C-allele homozygosity in rs6897932 ('CC'). However, underlying...

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PMID: 28181541
DOI: 10.1038/srep42036
PMCID: PMC5299473

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