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Article

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

16 May 2014

Abstract excerpt

Ribonucleotide reductase (RNR) plays a critical role in catalyzing the biosynthesis and maintaining the intracellular concentration of 4 deoxyribonucleoside triphosphates (dNTPs). Unbalanced or deficient dNTP pools cause serious genotoxic consequences. Autophagy is the process by which cytoplasmic constituents are degraded in lysosomes to maintain cellular homeostasis and bioenergetics. However, the role of...

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PMID: 24905824
DOI: 10.4161/auto.28954

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