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Article

P53 suppresses ribonucleotide reductase via inhibiting mTORC1.

Oncotarget - 20 Jun 2017

He Zhengfu, Hu Xing, Liu Weijin, Dorrance Adrienne, Garzon Ramiro, Houghton Peter J, Shen Changxian

Abstract excerpt

Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2 (RRM2) via inhibiting mammalian target of rapamycin complex 1 (mTORC1). In vitro, cancer cell lines and mouse embryonic fibroblast cells were...

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Source

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Identifiers

PMID: 28507282
DOI: 10.18632/oncotarget.17440
PMCID: PMC5522210

Genes

RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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