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Article

The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome

2020-06-28

Abstract excerpt

The small non-coding vault RNA (vtRNA) 1-1 has been shown to confer apoptosis resistance in several malignant cell lines and also to modulate the autophagic flux in hepatocytes, thus highlighting its pro-survival role. Here we describe a new function of vtRNA1-1 in regulating in vitro and in vivo tumor cell proliferation, tumorigenesis and chemoresistance. By activating extracellular signal-regulated kinases (ER...

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Identifiers and source

Literature Corpus work
4f110180-5b4a-5904-b6fc-3804c78288a7
DOI
10.1101/2020.06.28.175810
Open publication

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The human vault RNA enhances tumorigenesis and chemoresistance through the lysosomeDOI 10.1101/2020.06.28.175810
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