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Article

microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination

18 Apr 2012

Abstract excerpt

MicroRNAs (miRNAs) are an emerging group of short, noncoding RNAs that play an important role in regulating expression of classical genes. Thus far little is known about their role in autoimmune demyelination. In this study, we analyzed changes in the miRNA profile in CD4(+) T cells that occurred during the recognition of the myelin autoantigen, MOG(35-55). We found that, both in vivo and in vitro, myelin antigen...

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PMID: 22517757
DOI: 10.1073/pnas.1114325109

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