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Article

Natalizumab restores aberrant mi<scp>RNA</scp>expression profile in multiple sclerosis and reveals a critical role for miR‐20b

5 Dec 2014

Abstract excerpt

OBJECTIVE: To identify microRNAs (miRNAs) regulated by anti-α4 integrin monoclonal antibody therapy (natalizumab) in the peripheral blood of patients with relapsing-remitting (RR) multiple sclerosis (MS) and to confirm their role in experimental settings in vivo. METHODS: In a longitudinal study of 17 RR-MS patients, we investigated blood miRNA expression profiles at baseline and after 1 year of natalizumab...

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PMID: 25642434
DOI: 10.1002/acn3.152

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