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Article

Human cellular differences in cAMP ‐ CREB signaling correlate with light‐dependent melatonin suppression and bipolar disorder

5 Jun 2014

Abstract excerpt

Various lines of evidence suggest a mechanistic role for altered cAMP-CREB (cAMP response element - binding protein) signaling in depressive and affective disorders. However, the establishment and validation of human inter-individual differences in this and other major signaling pathways has proven difficult. Here, we describe a novel lentiviral methodology to investigate signaling variation over long periods of...

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PMID: 24898566
DOI: 10.1111/ejn.12602

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