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Article

A functional variant in NKX3.1 associated with prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2014

Martinez Erin E, Darke Amy K, Tangen Catherine M, Goodman Phyllis J, Fowke Jay H, Klein Eric A, Abdulkadir Sarki A

Abstract excerpt

NKX3.1 is an androgen-regulated prostate tumor suppressor protein. We previously found that antioxidant administration (N-acetylcysteine) in the Nkx3.1 knockout mouse model promoted prostate epithelial proliferation, suggesting that NKX3.1 activity modifies the effect of antioxidant administration on prostate carcinogenesis. Interestingly, administration of the antioxidant vitamin E significantly increased...

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Identifiers

PMID: 24894197
DOI: 10.1158/1940-6207.CAPR-14-0075
PMCID: PMC4154984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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