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Article

Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesis.

Cancer research - 1 Aug 2005

Ouyang Xuesong, DeWeese Theodore L, Nelson William G, Abate-Shen Cory

Abstract excerpt

Despite the significance of oxidative damage for carcinogenesis, the molecular mechanisms that lead to increased susceptibility of tissues to oxidative stress are not well-understood. We now report a link between loss of protection against oxidative damage and loss-of-function of Nkx3.1, a homeobox gene that is known to be required for prostatic epithelial differentiation and suppression of prostate cancer. Using...

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Identifiers

PMID: 16061659
DOI: 10.1158/0008-5472.CAN-05-1948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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