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Article

Targeting the DNA damage response in oncology

3 Apr 2012

Abstract excerpt

PURPOSE OF REVIEW: The success of poly(ADP-ribose) polymerase inhibition in BRCA1 or BRCA2 deficient tumors as an anticancer strategy provided proof-of-concept for a synthetic lethality approach in oncology. There is therefore now active interest in expanding this approach to include other agents targeting the DNA damage response (DDR). We review lessons learnt from the development of inhibitors against DNA...

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PMID: 22476188
DOI: 10.1097/cco.0b013e32835280c6

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