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Article

Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains.

Antimicrobial agents and chemotherapy - 1 Jun 2010

Castanheira Mariana, Woosley Leah N, Diekema Daniel J, Messer Shawn A, Jones Ronald N, Pfaller Michael A

Abstract excerpt

We evaluated the prevalence of fks1 hot spot (HS) 1 mutations among 133 Candida strains from six species displaying various caspofungin MIC values (from < or =0.008 to >8 microg/ml). Only 4 (2.9%) strains displayed FKS1 HS1 amino acid substitutions: 1 C. albicans (F641Y) among 32 isolates tested (3.1%), 1 C. glabrata (S645P) among 34 isolates tested (2.9%), and 2 C. tropicalis (F641S) among 12 isolates tested...

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Antifungal Agents
Candida
Candida albicans
Candida glabrata
Candidiasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Fungal

In Vitro Techniques

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Identifiers

PMID: 20368396
DOI: 10.1128/AAC.01711-09
PMCID: PMC2876398

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