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Article

Nerve conduction abnormalities and neuromyotonia in genetically engineered mouse models of human hereditary neuropathies.

Annals of the New York Academy of Sciences - 14 Sept 1999

Zielasek J, Toyka K V

Abstract excerpt

We performed electrophysiological studies in myelin protein mutant mice in order to characterize nerve conduction changes. We performed neurographic studies on the facial and sciatic nerves and needle electromyography (EMG). Mice homozygously deficient for the peripheral myelin protein 22 gene (Pmp22-/-) exhibited increased motor latencies, reduced nerve conduction velocities, and polyphasia of the M-response,...

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Source

Identifiers

PMID: 10586256

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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