Article
Imaging genomic mapping of an invasive MRI phenotype predicts patient outcome and metabolic dysfunction: a TCGA glioma phenotype research group project.
BMC medical genomics - 2 Jun 2014
Colen Rivka R, Vangel Mark, Wang Jixin, Gutman David A, Hwang Scott N, Wintermark Max, Jain Rajan, Jilwan-Nicolas Manal, Chen James Y, Raghavan Prashant, Holder Chad A, Rubin Daniel, Huang Eric, Kirby Justin, Freymann John, Jaffe Carl C, Flanders Adam, Zinn Pascal O
Abstract excerpt
BACKGROUND: Invasion of tumor cells into adjacent brain parenchyma is a major cause of treatment failure in glioblastoma. Furthermore, invasive tumors are shown to have a different genomic composition and metabolic abnormalities that allow for a more aggressive GBM phenotype and resistance to therapy. We thus seek to identify those genomic abnormalities associated with a highly aggressive and invasive GBM...
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