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CHOPPI: A web tool for the analysis of immunogenicity risk from host cell proteins in CHO‐based protein production

2 Jun 2014

Abstract excerpt

Despite high quality standards and continual process improvements in manufacturing, host cell protein (HCP) process impurities remain a substantial risk for biological products. Even at low levels, residual HCPs can induce a detrimental immune response compromising the safety and efficacy of a biologic. Consequently, advanced-stage clinical trials have been cancelled due to the identification of antibodies...

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PMID: 24888712
DOI: 10.1002/bit.25286

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