Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

doi:10.1038/ncomms4983

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Article

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

Nature communications - 2 Jun 2014

Ko Arthur, Cantor Rita M, Weissglas-Volkov Daphna, Nikkola Elina, Reddy Prasad M V Linga, Sinsheimer Janet S, Pasaniuc Bogdan, Brown Robert, Alvarez Marcus, Rodriguez Alejandra, Rodriguez-Guillen Rosario, Bautista Ivette C, Arellano-Campos Olimpia, Muñoz-Hernández Linda L, Salomaa Veikko, Kaprio Jaakko, Jula Antti, Jauhiainen Matti, Heliövaara Markku, Raitakari Olli, Lehtimäki Terho, Eriksson Johan G, Perola Markus, Lohmueller Kirk E, Matikainen Niina, Taskinen Marja-Riitta, Rodriguez-Torres Maribel, Riba Laura, Tusie-Luna Teresa, Aguilar-Salinas Carlos A, Pajukanta Päivi

Abstract excerpt

Dyslipidemia and obesity are especially prevalent in populations with Amerindian backgrounds, such as Mexican-Americans, which predispose these populations to cardiovascular disease. Here we design an approach, known as the cross-population allele screen (CPAS), which we conduct prior to a genome-wide association study (GWAS) in 19,273 Europeans and Mexicans, in order to identify Amerindian risk genes in...

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PMID: 24886709
DOI: 10.1038/ncomms4983
PMCID: PMC4062071

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SIK3
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