Article
Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations.
Communications biology - 28 Jul 2021
Yang Chaojie, Hallmark Brian, Chai Jin Choul, O'Connor Timothy D, Reynolds Lindsay M, Wood Alexis C, Seeds Michael, Chen Yii-Der Ida, Steffen Lyn M, Tsai Michael Y, Kaplan Robert C, Daviglus Martha L, Mandarino Lawrence J, Fretts Amanda M, Lemaitre Rozenn N, Coletta Dawn K, Blomquist Sarah A, Johnstone Laurel M, Tontsch Chandra, Qi Qibin, Ruczinski Ingo, Rich Stephen S, Mathias Rasika A, Chilton Floyd H, Manichaikul Ani
Abstract excerpt
Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.