Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos.

doi:10.1016/j.gene.2018.08.076

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Article

Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos.

Gene - 30 Dec 2018

Cid-Soto Miguel A, Martínez-Hernández Angélica, García-Ortíz Humberto, Córdova Emilio J, Barajas-Olmos Francisco, Centeno-Cruz Federico, Contreras-Cubas Cecilia, Mendoza-Caamal Elvia C, Ciceron-Arellano Isabel, Morales-Rivera Monserrat I, Jimenez-Ruiz Juan L, Salas-Martínez Guadalupe, Saldaña-Álvarez Yolanda, Revilla-Monsalve Cristina, Islas-Andrade Sergio, Orozco Lorena

Abstract excerpt

Amerindian ancestry appears to be a risk factor for metabolic diseases (MetD), making Mexicans an ideal population to better understand the genetic architecture of metabolic health. In this study, we determine the association of genetic variants previously reported with metabolic entities, in two Mexican populations, including the largest sample of Amerindians reported to date. We investigated the association of...

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PMID: 30176313
DOI: 10.1016/j.gene.2018.08.076

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