Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

doi:10.1038/srep19429

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Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

Scientific reports - 19 Jan 2016

Below Jennifer E, Parra Esteban J, Gamazon Eric R, Torres Jason, Krithika S, Candille Sophie, Lu Yingchang, Manichakul Ani, Peralta-Romero Jesus, Duan Qing, Li Yun, Morris Andrew P, Gottesman Omri, Bottinger Erwin, Wang Xin-Qun, Taylor Kent D, Ida Chen Y-D, Rotter Jerome I, Rich Stephen S, Loos Ruth J F, Tang Hua, Cox Nancy J, Cruz Miguel, Hanis Craig L, Valladares-Salgado Adan

Abstract excerpt

We performed genome-wide meta-analysis of lipid traits on three samples of Mexican and Mexican American ancestry comprising 4,383 individuals, and followed up significant and highly suggestive associations in three additional Hispanic samples comprising 7,876 individuals. Genome-wide significant signals were observed in or near CELSR2, ZNF259/APOA5, KANK2/DOCK6 and NCAN/MAU2 for total cholesterol, LPL, ABCA1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26780889
DOI: 10.1038/srep19429
PMCID: PMC4726092

Genes

MAU2
NCAN
APOA5
ABCA1
CELSR2
LIPC
APOB
CETP
COPB1
CTC1
DOCK6
GCKR
LPL
PFAS
SAMM50
TRIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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