Discrepant alterations in main candidate genes among multiple primary melanomas.

doi:10.1186/1479-5876-12-117

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Article

Discrepant alterations in main candidate genes among multiple primary melanomas.

Journal of translational medicine - 8 May 2014

Colombino Maria, Sini MariaCristina, Lissia Amelia, De Giorgi Vincenzo, Stanganelli Ignazio, Ayala Fabrizio, Massi Daniela, Rubino Corrado, Manca Antonella, Paliogiannis Panagiotis, Rossari Susanna, Magi Serena, Mazzoni Laura, Botti Gerardo, Capone Mariaelena, Palla Marco, Ascierto Paolo A, Cossu Antonio, Palmieri Giuseppe

Abstract excerpt

BACKGROUND: Alterations in key-regulator genes of disease pathogenesis (BRAF, cKIT, CyclinD1) have been evaluated in patients with multiple primary melanoma (MPM). METHODS: One hundred twelve MPM patients (96 cases with two primary melanomas, 15 with three, and 1 with four) were included into the study. Paired synchronous/asynchronous MPM tissues (N=229) were analyzed for BRAF mutations and cKIT/CyclynD1 gene...

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Identifiers

PMID: 24885594
DOI: 10.1186/1479-5876-12-117
PMCID: PMC4023698

Genes

BRAF

Provenance

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