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Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro

24 May 2014

Abstract excerpt

BACKGROUND: Polycomb Group (PcG) proteins are chromatin modifiers involved in early embryonic development as well as in proliferation of adult stem cells and cancer cells. PcG proteins form large repressive complexes termed Polycomb Repressive Complexes (PRCs) of which PRC1 and PRC2 are well studied. Differentiation of human Embryonic Stem (hES) cells into insulin producing cells has been achieved to limited...

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PMID: 24885493
DOI: 10.1186/1471-2121-15-18

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