Article
Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes.
Biomedical engineering online - 1 May 2014
Girão-Silva Thais, Bassaneze Vinicius, Campos Luciene Cristina Gastalho, Barauna Valerio Garrone, Dallan Luis Alberto Oliveira, Krieger Jose Eduardo, Miyakawa Ayumi Aurea
Abstract excerpt
BACKGROUND: We and others have previously demonstrated that adipose-derived stem cells (ASCs) transplantation improve cardiac dysfunction post-myocardium infarction (MI) under hemodynamic stress in rats. The beneficial effects appear to be associated with pleiotropic factors due to a complex interplay between the transplanted ASCs and the microenvironment in the absence of cell transdifferentiation. In the...
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