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Article

Post-Translational Variants of Major Proteins in Amyotrophic Lateral Sclerosis Provide New Insights into the Pathophysiology of the Disease.

International journal of molecular sciences - 8 Aug 2024

Bedja-Iacona Léa, Richard Elodie, Marouillat Sylviane, Brulard Céline, Alouane Tarek, Beltran Stéphane, Andres Christian R, Blasco Hélène, Corcia Philippe, Veyrat-Durebex Charlotte, Vourc'h Patrick

Abstract excerpt

Post-translational modifications (PTMs) affecting proteins during or after their synthesis play a crucial role in their localization and function. The modification of these PTMs under pathophysiological conditions, i.e., their appearance, disappearance, or variation in quantity caused by a pathological environment or a mutation, corresponds to post-translational variants (PTVs). These PTVs can be directly or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39201350
DOI: 10.3390/ijms25168664
PMCID: PMC11354932

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