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Article

Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Aug 2006

Klinman Judith P

Abstract excerpt

Early studies of enzyme-catalysed hydride transfer reactions indicated kinetic anomalies that were initially interpreted in the context of a 'tunnelling correction'. An alternate model for tunnelling emerged following studies of the hydrogen atom transfer catalysed by the enzyme soybean lipoxygenase. This invokes full tunnelling of all isotopes of hydrogen, with reaction barriers reflecting the heavy atom,...

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Identifiers

PMID: 16873120
DOI: 10.1098/rstb.2006.1870
PMCID: PMC1647309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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