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Article

Quantum mechanical hydrogen tunneling in bacterial copper amine oxidase reaction.

Biochemical and biophysical research communications - 7 Apr 2006

Murakawa Takeshi, Okajima Toshihide, Kuroda Shun'ichi, Nakamoto Takuya, Taki Masayasu, Yamamoto Yukio, Hayashi Hideyuki, Tanizawa Katsuyuki

Abstract excerpt

A key step decisively affecting the catalytic efficiency of copper amine oxidase is stereospecific abstraction of substrate alpha-proton by a conserved Asp residue. We analyzed this step by pre-steady-state kinetics using a bacterial enzyme and stereospecifically deuterium-labeled substrates, 2-phenylethylamine and tyramine. A small and temperature-dependent kinetic isotope effect (KIE) was observed with...

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PMID: 16487484
DOI: 10.1016/j.bbrc.2006.01.150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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