Article
Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.
Nature cell biology - 1 Jul 2014
Urosevic Jelena, Garcia-Albéniz Xabier, Planet Evarist, Real Sebastián, Céspedes María Virtudes, Guiu Marc, Fernandez Esther, Bellmunt Anna, Gawrzak Sylwia, Pavlovic Milica, Mangues Ramon, Dolado Ignacio, Barriga Francisco M, Nadal Cristina, Kemeny Nancy, Batlle Eduard, Nebreda Angel R, Gomis Roger R
Abstract excerpt
The mechanisms that allow colon cancer cells to form liver and lung metastases, and whether KRAS mutation influences where and when metastasis occurs, are unknown. We provide clinical and molecular evidence showing that different MAPK signalling pathways are implicated in this process. Whereas ERK2 activation provides colon cancer cells with the ability to seed and colonize the liver, reduced p38 MAPK signalling...
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