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Article

Cardiomyocyte cell cycle control and growth estimation in vivo—an analysis based on cardiomyocyte nuclei

13 Jan 2010

Abstract excerpt

AIMS: Adult mammalian cardiomyocytes are traditionally viewed as being permanently withdrawn from the cell cycle. Whereas some groups have reported none, others have reported extensive mitosis in adult myocardium under steady-state conditions. Recently, a highly specific assay of 14C dating in humans has suggested a continuous generation of cardiomyocytes in the adult, albeit at a very low rate. Mice represent...

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PMID: 20071355
DOI: 10.1093/cvr/cvq005

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