Article

Mitochondria Clearance Enables Macrophage-Driven Maturation of iPSC-Derived Cardiomyocyte Metabolism

2025-09-05

Abstract excerpt

Generation of functional engineered myocardial tissue remains a challenge, owing in part to lacking maturity of stem cell-derived cardiomyocytes. Current strategies to mature these cells fall short of achieving in vivo-like physiology. Macrophages, members of the innate immune system, reside in the heart and exert positive effects on cardiomyocyte function. We hypothesized that developmentally informed addition of...

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Literature Corpus work: 17cc2fa8-ea1f-5ab8-86de-ec5193dce25f
DOI: 10.1101/2025.09.02.673264

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