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Article

A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component.

Infection and immunity - 1 Aug 2014

Solans Luis, Aguiló Nacho, Samper Sofía, Pawlik Alexandre, Frigui Wafa, Martín Carlos, Brosch Roland, Gonzalo-Asensio Jesús

Abstract excerpt

The ESX-1 secreted virulence factor ESAT-6 is one of the major and most well-studied virulence factors of Mycobacterium tuberculosis, given that its inactivation severely attenuates virulent mycobacteria. In this work, we show that clinical isolates of M. tuberculosis produce and secrete larger a...

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Share to Antigens, Bacterial
Share to Bacterial Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 24891105
DOI: 10.1128/IAI.01824-14
PMCID: PMC4136221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24891105-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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