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Article

Regional biases in mutation screening due to intratumoural heterogeneity of prostate cancer.

The Journal of pathology - 1 Aug 2014

Kim Tae-Min, Jung Seung-Hyun, Baek In-Pyo, Lee Sung-Hak, Choi Youn-Jin, Lee Ji-Youl, Chung Yeun-Jun, Lee Sug-Hyung

Abstract excerpt

Intratumoural heterogeneity (ITH) leads to regional biases of the mutational landscape in a single tumour and may influence the single biopsy-based clinical diagnosis and treatment decision. To evaluate the extent of ITH in unifocal prostate cancers (PCAs), we analysed multiple regional biopsies from three PCAs, using whole-exome sequencing, DNA copy number and gene expression profiling analyses. A substantial...

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Source

Identifiers

PMID: 24870262
DOI: 10.1002/path.4380

Genes

ERG
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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