Article
Tumor and endothelial cell hybrids participate in glioblastoma vasculature.
BioMed research international - 1 Jan 2014
El Hallani Soufiane, Colin Carole, El Houfi Younas, Idbaih Ahmed, Boisselier Blandine, Marie Yannick, Ravassard Philippe, Labussière Marianne, Mokhtari Karima, Thomas Jean-Léon, Delattre Jean-Yves, Eichmann Anne, Sanson Marc
Abstract excerpt
BACKGROUND: Recently antiangiogenic therapy with bevacizumab has shown a high but transient efficacy in glioblastoma (GBM). Indeed, GBM is one of the most angiogenic human tumors and endothelial proliferation is a hallmark of the disease. We therefore hypothesized that tumor cells may participate in endothelial proliferation of GBM. MATERIALS AND METHODS: We used EGFR FISH Probe to detect EGFR amplification and...
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