Article
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.
Neuro-oncology - 1 Dec 2016
Eskilsson Eskil, Rosland Gro V, Talasila Krishna M, Knappskog Stian, Keunen Olivier, Sottoriva Andrea, Foerster Sarah, Solecki Gergely, Taxt Torfinn, Jirik Radovan, Fritah Sabrina, Harter Patrick N, Välk Kristjan, Al Hossain Jubayer, Joseph Justin V, Jahedi Roza, Saed Halala S, Piccirillo Sara G, Spiteri Inma, Leiss Lina, Euskirchen Philipp, Graziani Grazia, Daubon Thomas, Lund-Johansen Morten, Enger Per Øyvind, Winkler Frank, Ritter Christoph A, Niclou Simone P, Watts Colin, Bjerkvig Rolf, Miletic Hrvoje
Abstract excerpt
BACKGROUND: Amplification of the epidermal growth factor receptor (EGFR) and its mutant EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most frequent and most aggressive primary brain tumor. METHODS: In the present work, we analyzed the clonal evolution of these major EGFR aberrations in a small cohort of GBM patients using a unique surgical multisampling technique. Furthermore,...
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