Article
Emergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reports.
Antimicrobial agents and chemotherapy - 1 Aug 2014
Cottrell Gilles, Musset Lise, Hubert Véronique, Le Bras Jacques, Clain Jérôme
Abstract excerpt
The usefulness of atovaquone-proguanil (AP) as an antimalarial treatment is compromised by the emergence of atovaquone resistance during therapy. However, the origin of the parasite mitochondrial DNA (mtDNA) mutation conferring atovaquone resistance remains elusive. Here, we report a patient-based stochastic model that tracks the intrahost emergence of mutations in the multicopy mtDNA during the first...
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