Article
Human-specific features and developmental dynamics of the brain N-glycome
2023-01-11
Abstract excerpt
Comparative “omics” studies have revealed unique aspects of human neurobiology, yet an evolutionary perspective of the brain N-glycome is lacking. Here, we performed multi-regional characterization of rat, macaque, chimpanzee, and human brain N-glycomes using chromatography and mass spectrometry, then integrated these data with complementary glycotranscriptomic data. We found that in primates the brain N-glycome h...
Topics
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- Alzheimer's disease research and treatments
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Lysosomal Storage Disorders Research
- Machine Learning in Bioinformatics
- Pancreatic function and diabetes
- Proteoglycans and glycosaminoglycans research
- Xenotransplantation and immune response
Identifiers and source
- Literature Corpus work
- 003d1366-ab44-51f2-8469-2bb48dcd4d75
- DOI
- 10.1101/2023.01.11.523525
