Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Jul 2014

Bastiaans E, Aanen D K, Debets A J M, Hoekstra R F, Lestrade B, Maas M F P M

Abstract excerpt

The replication and segregation of multi-copy mitochondrial DNA (mtDNA) are not under strict control of the nuclear DNA. Within-cell selection may thus favour variants with an intracellular selective advantage but a detrimental effect on cell fitness. High relatedness among the mtDNA variants of an individual is predicted to disfavour such deleterious selfish genetic elements, but experimental evidence for this...

Topics

Aging
DNA Replication
DNA, Mitochondrial
Genetic Variation
Mitochondria
Mutagenesis, Insertional
Neurospora
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 24864316
DOI: 10.1098/rstb.2013.0448
PMCID: PMC4032522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora.PMID 24864316Read ↗

Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.Semantic proximity Read ↗

A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations.Semantic proximity Read ↗

Premeiotic instability of repeated sequences in Neurospora crassa.Semantic proximity Read ↗

Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck.Semantic proximity Read ↗

Association between variant plasmid formation and senescence in retroplasmid-containing strains of Neurospora spp.Semantic proximity Read ↗

Asexual transmission, non-suppressiveness and meiotic extinction of small plasmid-like derivatives of the mitochondrial DNA in Neurospora crassa.Semantic proximity Read ↗

The causes of mutation accumulation in mitochondrial genomes.Semantic proximity Read ↗

Suppression of cytoplasmic senescence in Neurospora.Semantic proximity Read ↗

Vegetative incompatibility in Neurospora: its effect on horizontal transfer of mitochondrial plasmids and senescence in natural populations.Semantic proximity Read ↗

Mitochondria: A Microcosm of Darwinian Competition.Semantic proximity Read ↗

Somatic deficiency causes reproductive parasitism in a fungus.Semantic proximity Read ↗

Evolutionary Trajectories are Contingent on Mitonuclear Interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.