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Structural and biochemical characterization of the folyl‐poly‐γ‐<scp>l</scp>‐glutamate hydrolyzing activity of human glutamate carboxypeptidase <scp>II</scp>

26 May 2014

Abstract excerpt

In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-γ-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Despite the role of GCPII as a folate hydrolase, nothing...

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PMID: 24863754
DOI: 10.1111/febs.12857

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