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Genome-wide methylation and expression profiling identify methylation-associated genes in colorectal cancer.

Epigenomics - 1 Jan 2020

Sun Xiaohui, Chen Diyu, Jin Ziqi, Chen Tianhui, Lin Aifen, Jin Hongchuan, Zhu Yimin, Lai Maode

Abstract excerpt

Aim: To identify methylation-associated genes in the carcinogenesis of colorectal cancer (CRC). Materials & methods: Genome-wide patterns of DNA methylation and gene expression in CRC tissues and adjacent normal tissues were determined and further validated in The Cancer Genome Atlas data and Chinese CRC patients, respectively. Gene overexpression and knockdown cells were constructed to investigate their...

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PMID: 31833403
DOI: 10.2217/epi-2019-0133

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