Article
miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis.
eLife - 23 May 2014
Chapnik Elik, Rivkin Natalia, Mildner Alexander, Beck Gilad, Pasvolsky Ronit, Metzl-Raz Eyal, Birger Yehudit, Amir Gail, Tirosh Itay, Porat Ziv, Israel Liron L, Lellouche Emmanuel, Michaeli Shulamit, Lellouche Jean-Paul M, Izraeli Shai, Jung Steffen, Hornstein Eran
Abstract excerpt
Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer that controls the differentiation and function of various cellular systems, including hematopoietic cells. miR-142 is one of the most prevalently expressed miRNAs within the hematopoietic lineage. To address the in vivo functions of miR-142, we utilized a novel reporter and a loss-of-function mouse allele that we have recently...
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