Article
The perlecan fragment LG3 regulates homing of mesenchymal stem cells and neointima formation during vascular rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 May 2015
Pilon E A, Dieudé M, Qi S, Hamelin K, Pomerleau L, Beillevaire D, Durocher Y, Zutter M, Coutu D, Perreault C, Hébert M J
Abstract excerpt
Transplant vasculopathy is associated with neointimal accumulation of recipient-derived mesenchymal stem cells. Increased circulating levels of LG3, a C-terminal fragment of perlecan, were found in renal transplant patients with vascular rejection. Here, we evaluated whether LG3 regulates the migration and homing of mesenchymal stem cells and the accumulation of recipient-derived neointimal cells. Mice were...
Topics
- Animals
- Aorta
- Blood Vessel Prosthesis
- Carotid Intima-Media Thickness
- Cell Movement
- Extracellular Signal-Regulated MAP Kinases
- Graft Rejection
- Green Fluorescent Proteins
- Heparan Sulfate Proteoglycans