Exfoliatin-Producing Strains Define a Fourth <i>agr</i> Specificity Group in <i>Staphylococcus aureus</i>

Abstract excerpt

The staphylococcal virulon is activated by the density-sensing agr system, which is autoinduced by a short peptide (autoinducing peptide [AIP]) processed from a propeptide encoded by agrD. A central segment of the agr locus, consisting of the C-terminal two-thirds of AgrB (the putative processing enzyme), AgrD, and the N-terminal half of AgrC (the receptor), shows striking interstrain variation. This finding has...

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