Article
Genetic susceptibility to the cross-reactivity of aromatic antiepileptic drugs-induced cutaneous adverse reactions.
Epilepsy research - 1 Aug 2014
Wang Wei, Hu Fa-Yun, Wu Xin-Tong, An Dong-Mei, Yan Bo, Zhou Dong
Abstract excerpt
BACKGROUND: The cross-allergic reactions among aromatic antiepileptic drugs (AEDs) are common, but little is known about the genetic mechanisms. PURPOSE: The aim of this study was to investigate the genetic associations of the human leukocyte antigen (HLA) genes with the cross-reactivity of cutaneous adverse drug reactions (cADRs) induced by different aromatic AEDs. METHODS: We reviewed 60 Chinese patients with a...
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