Article
TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling.
Cell - 22 May 2014
Riera Céline E, Huising Mark O, Follett Patricia, Leblanc Mathias, Halloran Jonathan, Van Andel Roger, de Magalhaes Filho Carlos Daniel, Merkwirth Carsten, Dillin Andrew
Abstract excerpt
The sensation of pain is associated with increased mortality, but it is unknown whether pain perception can directly affect aging. We find that mice lacking TRPV1 pain receptors are long-lived, displaying a youthful metabolic profile at old age. Loss of TRPV1 inactivates a calcium-signaling cascade that ends in the nuclear exclusion of the CREB-regulated transcriptional coactivator CRTC1 within pain sensory...
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